Information on the GAP Study can be found here

Contact Information

Chief Investigator: Dr Ben Gibbison 

Lead Applicant: Professor Chris Rogers

Study coordinator: Sarah Baos

E-mailgap-study@bristol.ac.uk

 

Mesothelioma and Radical Surgery 2: a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma (MARS 2)

Funder acknowledgement: National Institute for Health Research Health Technology Assessment Programme

REC Number: 13/LO/1481

Status: Recruiting

Mesothelioma is a cancer of the thin membrane that lines the chest. Around 2500 people in the UK are diagnosed with mesothelioma each year. Exposure to asbestos is the most common cause although the cancer does not usually become apparent until 40-60 years after exposure. Anti-cancer drugs (chemotherapy) are usually given to help treat mesothelioma and sometimes lung-sparing surgery (pleurectomy decortication) is undertaken. However, it is not known if this surgery, in addition to chemotherapy, can increase survival and improve the quality of life for patients. The aim of the MARS2 study is to compare surgery – (extended) pleurectomy decortication – with no surgery with respect to overall survival, cost-effectiveness and quality of life by phone at regular intervals for 2 years. Patients will be asked to complete and return a Quality of Life Questionnaire at these time points. MARS 2 also includes an optional ‘Information study’, where consenting patients may be interviewed or have their consultations audio-recorded. The aim of the Information study is to explore how a patient makes a decision to take part in research or not, with the overall aim of improving recruitment to clinical trials. 

 

Contact Information

Chief Investigator: Mr Eric Lim

Trial Co-Ordinator: Ms Kate Ashton

E-mail: mars2-trial@bristol.ac.uk

 

Video Assisted Thoracoscopic Lobectomy Versus Conventional Open Lobectomy For Lung Cancer, A Multi-Centre Randomised Controlled Trial With An Internal Pilot:

The VIOLET Study

Funder: NIHR/HTA 

Sponsor: Royal Brompton and Harefield NHS Foundation Trust 

REC Number: 14/LO/2129

Status: Recruiting

Lung cancer is the leading cause of cancer death worldwide and survival in the UK remains amongst the lowest in Europe. Surgery is the main method of managing early stage disease with over 5000 resections being performed for primary lung cancer within the UK in 2010. Of these, the majority (75%) involved surgical excision of the pulmonary lobe containing the tumour (lobectomy), which is the standard treatment strategy for patients with early stage non-small cell lung cancer.

This type of surgery can be undertaken via traditional open surgery or a form of keyhole surgery called video assisted thoracoscopic surgery (VATS). Both ways of performing the operation are currently used within the NHS and both aim to remove the lobe of the lung containing the tumour. However, at present, we do not know which offers the best treatment and recovery for patients.

Therefore, the aim of the VIOLET study is to generate high quality evidence to compare clinical and patient-reported outcomes between VATS and open surgery in a randomised controlled trial (RCT). A well designed and conducted RCT comparing the effectiveness and cost-effectiveness of VATS and open surgery is urgently needed to inform current NHS practice, health policy and individual surgeon and patient decision-making.

The VIOLET study will involve 500 patients recruited from several hospitals across the UK. The study design includes an internal pilot phase to ensure deliverability of the full RCT.

The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the HTA, NIHR, NHS or the Department of Health.

Contact Information

Chief Investigator: Mr Eric Lim, Consultant Thoracic Surgeon, Royal Brompton Hospital

Study coordinator: Lucy Dabner

E-mailviolet-study@bristol.ac.uk

Further information can be found on Cancer Research UK